Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model
PHARMACEUTICS, 14, 2022
Leonor Côrte-Real , Ana Rita Brás , Adhan Pilon , Nuno Mendes , Ana Sofia Ribeiro , Tiago D. Martins , José Paulo Farinha , M. Conceição Oliveira , Fatima Gartner , M. Helena Garcia , Ana Preto , Andreia Valente

Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods
BIOMETALS, 34, 1029-1042 2021
Filipa C. Santos , Paulo J. Costa , M. Helena Garcia , Tânia S. Morais

Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds
INORGANIC CHEMISTRY FRONTIERS, 8, 1983-1996 4 2021
Ricardo G. Teixeira , Dimas C. Belisario , Xavier Fontrodona , Isabel Romero , Ana Isabel Tomaz , M. Helena Garcia , Chiara Riganti , Andreia Valente

Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action
DALTON TRANSACTIONS, 50, 1845-1865 2 2021
Diogo Sequeira , Pedro V. Baptista , Ruben Valente , M. Fatima M. Piedade , M. Helena Garcia , Tânia S. Morais , Alexandra R. Fernandes

Novel ruthenium cyclopentadienyl - peptide conjugate complexes against human FGFR(+) breast cancer
DALTON TRANSACTIONS, 49, 5974-5987 5 2020
J. Franco Machado , Miguel Machuqueiro , Fernanda M. Marques , M Paula Robalo , M.Fatima M.Piedade , M. Helena Garcia , Joao D. G. Correia , Tânia S. Morais

A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells
MOLECULES, 25, 4 2020
Adhan Pilon , Ana Rita Brás , Leonor Côrte-Real , Fernando Avecilla , Paulo J. Costa , Ana Preto , M. Helena Garcia , Andreia Valente

New copper(i) complexes selective for prostate cancer cells
DALTON TRANSACTIONS, 49, 12273-12286 9 2020
J. Franco Machado , Diogo Sequeira , Fernanda M. Marques , M. Fatima M. Piedade , Maria J. Villa de Brito , M. Helena Garcia , A.R. Fernandes , Tânia S. Morais

Ruthenium carboranyl complexes with 2,2 -bipyridine derivatives for potential bimodal therapy application
RSC ADVANCES, 10, 16266-16276 4 2020
Ricardo G. Teixeira , Fernanda M. Marques , M Paula Robalo , Xavier Fontrodona , M. Helena Garcia , Simonetta Geninatti Crich , Clara Vinas , Andreia Valente

First heterobimetallic Cu(i)-dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity
NEW JOURNAL OF CHEMISTRY, 43, 12308-12317 8 2019
Catarina Bravo , M Paula Robalo , Fernanda M. Marques , Alexandra R. Fernandes , Diogo A. Sequeira , M. Fatima M. Piedade , M. Helena Garcia , Maria J. Villa de Brito , Tânia S. Morais

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 163, 853-863 2 2019
Leonor Côrte-Real , Brittany Karas , Patricia Girio , Alexis Moreno , Fernando Avecilla , Fernanda M. Marques , Brian T. Buckley , Keith R. Cooper , Cathleen Doherty , Pierre Falson , M. Helena Garcia , Andreia Valente

Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect
INORGANIC CHEMISTRY, 58, 9135-9149 7 2019
Leonor Côrte-Real , Brittany Karas , Ana Rita Brás , Adhan Pilon , Fernando Avecilla , Fernanda Marques , Ana Preto , Brian T. Buckley , Keith R. Cooper , Cathleen Doherty , M. Helena Garcia , Andreia Valente

Polymer ruthenium-cyclopentadienyl conjugates - New emerging anti-cancer drugs
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 168, 373-384 4 2019
Tiago Moreira , Rita Francisco , Elisabeta Comsa , Sophie Duban-Deweer , Valerie Labas , Ana-Paula Teixeira-Gomes , Lucie Combes-Soia , Fernanda M. Marques , Antonio Matos , Audrey Favrelle , Cyril Rousseau , Philippe Zinck , Pierre Falson , M. Helena Garcia , Ana Preto , Andreia Valente

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
European Journal of Medicinal Chemistry , 143, 503-514 2018
Ricardo G. Teixeira , Ana Rita Brás , Leonor Côrte-Real , Rajendhraprasad Tatikonda , Anabela Sanches , M Paula Robalo , Fernado Avecilla , Tiago Moreira , M. Helena Garcia , Matti Haukka , Ana Preto , Andreia Valente

Methyl-cyclopentadienyl Ruthenium Compounds with 2,2?-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential
Inorganic Chemistry, , 4 2018
Leonor Côrte-Real , Ricardo G. Teixeira , Patricia Girio , Elisabeta Comsa , Alexis Moreno , Rachad Nasr , Hélène Baubichon-Cortay , Fernando Avecilla , Fernanda M. Marques , M Paula Robalo , Paulo Mendes , Joao P. Prates Ramalho , M. Helena Garcia , Pierre Falson , Andreia Valente

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 143, 503-514 1 2018
Ricardo G. Teixeira , Ana Rita Brás , Leonor Côrte-Real , Rajendhraprasad Tatikonda , Anabela Sanches , M Paula Robalo , Fernando Avecilla , Tiago Moreira , M. Helena Garcia , Matti Haukka , Ana Preto , Andreia Valente

Important cytotoxic and cytostatic effects of new copper(I)-phosphane compounds with N,N, N,O and N,S bidentate ligands
DALTON TRANSACTIONS, 47, 7819-7829 6 2018
Tânia S. Morais , Yann Jousseaume , M.Fatima M.Piedade , Catarina Roma-Rodrigues , A.R. Fernandes , Fernanda M. Marques , Maria J. Villa de Brito , M. Helena Garcia

New copper(I) and heteronuclear copper(I)-ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity
JOURNAL OF INORGANIC BIOCHEMISTRY, 169, 68-78 4 2017
Joao Lopes , David Alves , Tânia S. Morais , Paulo J. Costa , M.Fatima M.Piedade , Fernanda M. Marques , Maria J. Villa de Brito , M. Helena Garcia

Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes
JOURNAL OF INORGANIC BIOCHEMISTRY, 168, 27-37 3 2017
Orsolya Doemoetoer , R. F. M. de Almeida , Leonor Côrte-Real , Cristina P. Matos , Fernanda M. Marques , Antonio Matos , Carla Real , Tamas Kiss , Eve Anna Enyedy , M. Helena Garcia , Ana Isabel Tomaz

In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 17, 126-136 2017
Nuno Mendes , Francisco Tortosa , Andreia Valente , Fernanda M. Marques , Antonio Matos , Tânia S. Morais , Ana Isabel Tomaz , Fatima Gartner , M. Helena Garcia

New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 852, 34-42 12 2017
Adhan Pilon , Patricia Girio , Guilherme Nogueira , Fernando Avecilla , Harry Adams , Julia Lorenzo , M. Helena Garcia , Andreia Valente